Good question.
Get's into spine,and then I am lost.
there are some arrow experts here that will give you the answer.
I shoot a 60# Drenalin with a 27.5# DL. 100gr B.H.
I shoot the 250 CE Maxima hunters with 2" Blazers.
I like the arrows,and the Blazers hold up great.Am also happy with the groups.
I think I would get better penetration if I went with the 350's,as it increases KE, but it would slow the arrow down.
Also get's into spine.
You may be asking the same question I am.
Not sure.
I do know that every time I try and find out which is best, I get lost.
Good luck.