Yes....with ease actually. Here are my numbers as an example....430gr at 280fps and 74.9lbs/ke at the bow.
yds....k/e....fps
0....74.9....280
20....72.2....275
40....69.8....270.3
60....67.5....265.8
80....65.4....261.6
100....63.3....257.8
150....59.4....249.4
175....57.7....245.9
However....just because the equipment can, doesn't mean you can or even should try. To many factors can and will occur when shooting at a live animal and then throw environmental factor in on top of that and nothing good can come of it. Please, please do not take this the wrong way Poleaxe, as it is a blanket statement and not meant toward you directly. I don't mind posting stuff like this for educational reason and in a bit I will post the same except using a lighter arrow so you can see the true effects of a light vs. heavier arrow.