The biggest issue with the quota hunts is the "scouting" (and stand placements) that occurs the day before the quota hunt begins. This scouting can put more pressure on the deer than the actual hunting.
Most hunters ruin the seemingly good places they select by running the deer out the day before they hunt. Also, much of any visible deer sign such as rubs & scrapes is actually made at night, while the bucks tend to spend much of their days in different locations than their nights.
Most of the hunt compartments are more similar than different, main difference being as to whether the lake is on the east or west side of the compartment. The best area is any one for which you are already very familiar. If that is none, then you have better odds of being drawn by not limiting your choices in the draw.