Here's what I've learned about the wind and hunting in the mountains of East Tennessee:
1. It will change direction 80 times a day
2. Don't hunt down in a holler. The winds swirl and do all kinds of weird things. I very rarely - and I mean rarely hunt in a holler. Just too unpredictable with the wind.
3. Hunt high - I just hate hunting on the ground. I can get away with much more, as far as wind movement, up high.
4. As mentioned - terrain affects all of this. Bluffs, tree lines, fields, hollers, etc all effect eddies - making it difficult to predict. That is why I like to hunt high.
Summary - I try to hunt the prevailing winds as much as is possible hunting deer in large tracts of timber, stay out of hollers, hunt high (18'-25'+ - sometimes this is not possible during bow season with the canopy), cloudy/overcast/humid days are really tough for scent as scent seems to just linger low, clear sunny high pressure days are the best. JMHO.