IMO there's dead, eventually, and there's DRT. There is value in shocking the internals. Sure a small hole thru an animal, in the right spot, will kill them, but you may have to track, (some folks just like to track) but I've always tried to hit a little higher shoulder shots and rely on the shock from a good performing bullet to knock them down immediately if I can. I've never killed an elk, but the principle remains the same. I would imagine someone out there has probably killed an elk with a 22-250. Just my thoughts.