I've had a lot of different 22's over the years and they often shoot very differently with different ammo. Including different Ruger 10/22s, Savage and Marlin bolt actions, Browning semi-auto, Ruger 22/45s, Ruger Single Six, Star FM pistol, etc. etc. So when I go to the range to test a new gun I take these boxes with me. Lots of different varieties of ammo collected over the years. (The red label Winchester SuperX ammo is probably 40 yeas old and still shoots fine).
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Some semi-autos don't like loading/shooting hollow points but like RN solids. Some don't like standard or medium velocity rounds but shoot CCI Stingers and other high speed stuff fine. Accuracy differs widely between guns and ammo. I expect at least 1 inch or smaller groups at 50 yards before I try to whack small game in the head. Experiment with different ammo and it's possible to find that. But guns are just different with different action and barrel harmonics. I once had a blue Ruger 22/45 and a stainless steel 22/45 that shot different ammo totally differently.
As a general rule, you can't go wrong with CCI 22LR hollow points. Function well, accurate, and deadly in most all guns. They are packed in suspended plastic cases so the bullets don't bang into each other during shipping. Unlike bulk "boxed" ammo which is typically less accurate. My go-to ammo these days are usually CCI LR hollow points in case I really need to whack something like a coon caught in a DPCT, and I mostly hunt squirrels with Remington SubSonic hollow points, (quiet for urban adjacent areas), or even CCI Quiet ammo for close backyard squirrels or plinking with the grandkids.
Look at it this way. The more combinations of guns and ammo you get to try out the more fun you'll have.
