The ones we've been targeting are above 61 bridge a few miles, below peach orchard a couple of miles, and below the interstate.
You can run almost any sized boat up the river when it's generating, when it's off it isn't worth the effort to chase the stripers.
We whacked the poop out of them this weekend, and luckily took a bunch out of the river where they won't ever have the chance to kill trout again. Biggest fish was 47lbs, and most everyone was over 30 lbs.
Normally I am 100% catch and release no matter what I'm after, but there's nothing more satisfying than beating a stripers skull in and throwing it into the cooler.