Know your equipment, make sure it's working properly. If it's not your equipment's fault, it's you. Most people rush the shot, as they are in awe. They want to get a shot off because "he can't get away".
The reality is, the more big ones you can put on the ground and experience those moments, the easier it gets. It just has to happen for you.
I have a process. From the moment I even hear a deer coming, the gun is getting in hand and I'm taking note of wind direction (that may indicate when I may shoot). I hunt a lot of "just off winds", meaning it's almost perfect for them, and almost wrong for me…though I can still pull it off if he comes from the likely direction I have in mind. I keep my scope on 6x power and have one hand to adjust, if needed, but it always crosses my mind in my process. A lot of my shots are very close quarters, so I may turn it down to 3x power. As they approach, I'm picking shooting lanes. My gun is on him and I'm watching body language. That will tell you all you need to know and sometimes when to shoot.