I hunt with a .50 caliber T/C Hawken with 90 grains of Pyrodex behind a 350 grain maxi-ball hunter. Clover leafs at 50 yards. I've never used round balls. Always figured it was too much work.
I've always shot .490 with blue pillow ticking patch .018 patch per my measurement.
I have owned several TC Hawken & Renegades over the years a found 70 to 90 grain loads of fffg black powder work very well.
Try several variations of powder & patch combinations too see what your gun shoots best..