I have shot 3, all really were not on purpose, first was my first muzzle loader deer, open sights H&R 45cal, aimed at white spot on chest as he was facing me at 50-60y, when the smoke cleared he was flopping around, about the time I got reloaded he quit, rolled him over to gut and didn't see the bullet hole, the bullet went into the nostril and straight to the brain, cut every little bone in the roof of the mouth, no meat lose, 2nd was another muzzle loader deer, 2 ran in on top of me and 1 fell as I tried to get turned, they ran i made a noise and 1 stopped and turned head around to look back, the only shot was a Texas heart or the head, perfect hit, took the whole top of head along with brains and buttons with it, it happened so quick I really didn't have time to think just react, last 1 I heart shot and as it ran past me I put it on the nose, in through the ear out through the eye, again no idea why, I have passed up a lot of shots since those and no plans to ever do it again but dang instincts take over sometimes, Crappieluck asked me why I took a axe to the button bucks head, told him I didn't showed him the 1/2 of a 50 cal powerbelt hole , no other wound on him. looked to try to find top of head that was blown off but the pieces were so small I couldn't find any parts of the buttons. I reckon all the squirrel hunting I have done with a 22 has helped me be a decent shot but I wouldn't recommend a head shot if a neck shot is available.