In my experience big bucks do the same thing over & over, generation after generation. Once you find how they use a particular area you've got them by the balls because the terrain never changes and landscape rarely does, so if you kill a big buck here this year the chances are good you can kill another one next year same spot generally same time.
I approach it by first finding the major food source and scouting outward until I've identified where big bucks historically bed. Along the way I'll see where does bed. It's like playing connect the dots. I know there will be a line going from food to doe beds, to buck beds. Along that line I search for pinched areas where travel will be predictable. It could be subtle like the edge of a steep slope or edge of thicket, or it could be obvious like the top of a steep ravine where it's easier for a deer to walk around than down & back up. My favorites are "S" curves in a creek because the two curves will have high banks while the straight in between will have a shallow bank right at creek bottom level. It's easy to cross. Once I've identified all potential "pinches" I'll scout them to see which gets the most traffic, then I'll draw a line to connect the dots. I set up & hunt the pinches I feel best about, food end in the evenings and bed end in the mornings. Within a few sits I generally will have learned enough to tighten the noose and get on him. If I get him it's usually inside of three days of hunting. Generally beyond that I don't get him at all. He wins and I move on.
Probably unlike most hunters I don't give much credence to sign, and rarely if ever hunt over it. I pay attention to rubs in how high they are but not how big or tore up they are. A buck's neck is always stretched straight out or slightly down as he pushes against the tree. If it's knee high I know it's not a big bodied buck. If it's hip high I pay attention because a yearling 6pt can't get leverage that high up. For scrapes I look for numbers of scrapes that are fresh and I look for licking branches broken or stripped of leaves above my head. Lots of scrapes frequently opened usually means more than one older buck competing for the area, so my odds of getting on one are higher than if I'm in an area with only one big buck. The high licking branch is like the rubs. It takes a big bodied buck to reach 6ft-7ft up. Big bodies usually mean big racks. Old sign like old rubs, especially if apparent multiple years of high rubs means I'm in an area that holds big bucks every year.
That's what I look for. Long winded but really pretty simple and repeatable. Sure there are exceptions to every rule but I'm trying to play the odds, not defy them. The sign only lets me know if a good buck is in the area. Connecting the dots of travel let me know where to hang a stand. And you gotta know when you've lost. If you haven't gotten him within a few days, he's onto you. Any more time and you're spitting into the wind. You're best off finding the next buck. They are around. You're just probably not going to see a mature buck at a rub, scrape, or in the field during daylight, although it seems that's where everybody hunts. They actually cruise through open timber all times of day more than folks seem to think. You just gotta find the spots where his travel gets narrowed down inside a tight window and set up & wait......and wait......and wait. It's not uncommon for me to sit a day or two or three & never see the first deer, but I know when I do it'll probably be an old bruiser by himself with no apparent care in the world, and he'll be inside of 20yds to my stand. The other hunters are sitting over where he'll be at 2:30am, not pm. That's why I rarely encounter other hunters. We aren't hunting the same spots. Truth be told, most of my bucks were shot in places folks wouldn't expect to see a deer, let alone a good buck. That said, I know guys who get it done in the obvious places too. So who knows?